|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Our findings support the idea that TGF-beta(1) hyperexpression is a risk factor for hypertension and hypertensive complications and provides a mechanism for the excess burden of hypertension in blacks.
|
10725360 |
2000 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Expression of TGF-beta1 and its receptor genes (TbetaR I, TbetaR II, and TbetaR III-betaglycan) in peripheral blood leucocytes in patients with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome.
|
18097622 |
2008 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Conversely, P311-transgenic (P311(TG)) mice had elevated levels of TGF-β1-TGF-β3 and subsequent hypertension.
|
24091331 |
2013 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension.
|
29976656 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
These results suggested that ERK 1/2 could be activated by phosphorylation with over-expression of TGF-beta1 in the endothelium and in VSMC of aorta and renal arterioles from SHR, which might play an important role in VSMC proliferation under hypertension.
|
17364610 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Leptin, an adipocyte product, has been shown to play a role in obesity-related hypertension and in vitro studies demonstrated a biologic interaction between leptin and TGF-beta1.
|
12219869 |
2002 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Hypertension is associated with increased expression of FABP3, FAS, FN1, IL1R2, LPL, SERPINE1, TGFB1, and VCAM1 and decreased expression of SELPLG and SERPINEB2.
|
23337395 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Transforming growth factor‑β1 (TGF‑β1)/small mothers against decapentaplegic 3 (Smad3) is considered a potential therapeutic target for vascular remodeling in hypertension.
|
28791353 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In some, but not all, studies, IL6 -174G/C (rs1800795) and TGFB1 869T/C (rs1982073) gene polymorphisms have been associated with hypertension in the general population.
|
19106168 |
2009 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In the present study, we assessed whether the TGF-beta 1 gene is a candidate gene for coronary heart disease or hypertension.
|
8901839 |
1996 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Heart tissue was analyzed by histopathological morphometry, including assessments of ventricular and coronary vascular hypertrophy and fibrosis, as well as immunohistochemistry analyses of myocardial expression of AT<sub>1</sub>R. l-NAME treatment reduced the plasma nitrate level and led to the development of hypertension, with increased plasma levels of AT II and increased heart transcriptional levels of AT<sub>1</sub>R and TGF-β1-mediated connective tissue proteins, showing myocardial and coronary arteriolar hypertrophy and fibrosis.
|
28438687 |
2017 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We found that OSA combined with HSD increased the severity of hypertension through increasing level of blood Trimethylamine-Oxide (TMAO), release of Th1-related cytokine (IFN-γ) and inhibition of anti-inflammatory cytokine (TGF-β1), and affected the gut microbiome in rats, particularly by depleting Lactobacillus.
|
30784906 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats.
|
31254954 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
TGF-beta(1) may cause endothelial dysfunction in apolipoprotein E-deficient (apoE(-/-)) mice via stimulation of reactive oxygen species (ROS) production by the NADPH oxidase (NOX) system and aggravate aortic and heart remodeling and hypertension.
|
20511416 |
2010 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The expression of TGF-β1 was significantly elevated, whereas the expression of PI3KC3 was significantly downregulated in the patients with hypertension compared with controls.
|
30783440 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Benazepril, an angiotensin-converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting advanced glycation end-product-mediated pathways.
|
19018797 |
2009 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension.
|
18496036 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Our data provide evidence that calpain mediates EGF- and PDGF-induced collagen synthesis and proliferation of pulmonary artery smooth muscle cells via an intracrine TGF-β1 pathway in pulmonary hypertension.
|
22005303 |
2011 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Normally distributed square root of TGF-β1 (pg/ml) of hypertension cases (148.56 ± 66.46) was significantly higher than that of control (128.52 ± 65.11), P = 0.008.
|
24413999 |
2014 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Expression of TGF-beta1 mRNA was significantly higher in renal tissue from patients not receiving angiotensin converting enzyme inhibitor (ACEI) therapy for hypertension (P<0.05).
|
11740395 |
2001 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
These results suggest that the TGF-beta1 gene at chromosome 19q13.1 may be a candidate susceptibility locus for hypertension in Japanese women.
|
12032592 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
At similar levels of systemic hypertension, Dahl salt-sensitive but not spontaneously hypertensive rats (SHR) develop glomerular hypertension, which is accompanied by upregulation of transforming growth factor beta1 (TGF-beta1), mesangial matrix expansion, and sclerosis.
|
12771048 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In this study, the authors performed a meta-analysis to investigate the associations of +869T/C and +915G/C polymorphisms in TGF-β1 gene with hypertension risk in Chinese.
|
22209986 |
2012 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of the Central Chernozem Region.
|
18256755 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage.
|
18821144 |
2008 |